Antibiotic Substances from Basidiomycetes: III. Coprinus Similis and Lentinus Degener

Antibiotic Substances from Basidiomycetes: III. Coprinus Similis and Lentinus Degener.

* Journal Paper No. J-1578 of the Iowa Agricultural Experiment Station. Project No. 746. 1 Ajl, S. J., White, A. G. C., and Werkman, C. H., J. Bact., 54, 23 (1947). 2 Kalnitsky, G., Utter, M. F., and Werkman, C. H., Ibid., 49, 595-602 (1947). 3 Ochoa, S., J. Biol. Chem., 155, 87-100 (1944). 4 Quastel, J. H., and Wooldridge, W. R., Biochem. J., 22, 689-702 (1922). 5 Klotz, I. M., and Tietze, F.,...

Antibiotic Substances from Basidiomycetes Ix

Antibiotic Substances Separated from Sumac.

It has become evident (Osborn, 1943; Lucas and Lewis, 1944) that higher plants are potential sources of antibiotic agents. Several investigators (Little and Grubaugh, 1946; Atkinson and Rainsford, 1946; Sanders, Weatherwax, and McClung, 1945) have reported antibiotic effects of juices and of crude extracts of plants on various microorganisms. The active materials can be separated in some degree...

Coriolin, a new Basidiomycetes antibiotic.

Coprinol, a new antibiotic cuparane from a Coprinus species.

Coprinol, a new antibacterial cuparane, was isolated from fermentations of a Coprinus sp. Its biological activities were investigated and its structure was elucidated by spectroscopic methods. The new antibiotic exhibited activitiy against multidrug-resistant Gram-positive bacteria in vitro. Two derivatives were synthesized and their activities compared to the parent compound.